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The proposed pathways are biologically plausible and partly demonstrated in vitro

Furthermore, when comparing the metabolic responses to metreleptin treatment of patients with PPARG and LMNA pathogenic variants in the FPLD group, both groups reported remarkable and similar reductions in HbA1c, insulin dose, and triglyceride levels after 12 months of treatment (243)

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TABLE 3 Studies on recent research on Leishmania drug resistance